THE CONCENTRATION AND ACCUMULATION OF LIPIDS IN THE TUMOR COMPONENT OF A TUMOR–HOST ORGANISM, WALKER CARCINOMA 256 IN ALBINO RATS

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Abstract
A study was made of the lipid concentration and accumulation in the tumor component of a tumor–host organism at progressive intervals during its growth using Walker Carcinoma 256 in albino rats. At the end of each of 7, 14, 21, and 28 days of tumor growth, and covering the entire life history of Walker Carcinoma 256, 10 tumor–rat organisms were sacrificed and appropriate sections of the tumor removed for differential lipid analysis by oxidative micromethods. The outstanding feature revealed in these studies was the maintenance, throughout its life history, of high concentrations of phospholipid, free and esterified cholesterol in Walker Carcinoma 256, and the increasing accumulation of large amounts of these lipids in the tumor component of the tumor–host organism. There was no marked accumulation of neutral fat which, in the tumor, declined to almost l/10th its initial concentration concurrently with the visible loss of storage fat in the host component. A day or two before death, the central core of the tumor appeared necrotic, its concentration of phospholipid declined and its concentration of free cholesterol rose. Otherwise, the lipid composition of the tumor was uniform throughout the cross section.

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