Effect of Protein on the Toxicity of Hexachloronaphthalene

Publisher Website
Google Scholar
Abstract
The administration of as little as 3 to 4 mg of hexachloronaphthalene, total dose, over a one- or two-week experimental period, resulted in liver hypertrophy and the accumulation of liver fat in rats if the animals were fed a 9% casein diet. Increasing the casein in the diet to 18 or 27% at the expense of sucrose afforded a significant protection against liver fat accumulation both in the presence and in the absence of the highly chlorinated naphthalene. The protective effective of dietary protein against hexachloronaphthalene-induced fatty livers was expressed by a much more gradual increase in liver fat in animals receiving a high-protein diet contrasted with a rapid increase in animals receiving a 9% casein diet. Substitution of 20% of Crisco for an equal amount of casein in the diet, or omitting the vitamin A and D supplement, had no influence on the liver changes induced by hexachloronaphthalene.