Phospholipid signalling through phospholipase D and phosphatidic acid
Open Access
- 1 August 2006
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 58 (8) , 457-461
- https://doi.org/10.1080/15216540600871142
Abstract
Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the predominant membrane phospholipid, phosphatidylcholine producing phosphatidic acid and free choline. This activity can participate in signal transduction pathways and impact on vesicle trafficking for secretion and endocytosis, as well as receptor signalling. Phospholipids can regulate PLD activity directly, through specific intermolecular interactions, or indirectly, through their effect on the localization or activity of PLD's protein effectors. This short review highlights these various phospholipid inputs into the regulation of PLD activity and also reviews potential roles for PLD‐generated phosphatidic acid, particularly a mechanism by which the phospholipid may participate in the process of vesicular trafficking. iubmb Life, 58: 457 ‐ 461, 2006Keywords
This publication has 16 references indexed in Scilit:
- Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activityJournal of Cell Science, 2005
- Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic AcidJournal of Biological Chemistry, 2004
- Cytoskeletal regulation: rich in lipidsNature Reviews Molecular Cell Biology, 2004
- Phospholipase D1 Regulates Secretagogue-stimulated Insulin Release in Pancreatic β-CellsJournal of Biological Chemistry, 2004
- Protein-Lipid Interplay in Fusion and Fission of Biological MembranesAnnual Review of Biochemistry, 2003
- Mechanisms of Regulation of Phospholipase D1 by Protein Kinase CαJournal of Biological Chemistry, 2003
- A role for phospholipase D1 in neurotransmitter releaseProceedings of the National Academy of Sciences, 2001
- The cAMP-specific Phosphodiesterase PDE4D3 Is Regulated by Phosphatidic Acid BindingJournal of Biological Chemistry, 2000
- Phospholipase D and membrane traffic: Potential roles in regulated exocytosis, membrane delivery and vesicle buddingBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
- Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase systemBiochemical and Biophysical Research Communications, 1979