Transcriptional Analysis of the Principal Cell Division Gene, ftsZ , of Mycobacterium tuberculosis
- 1 April 2005
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 187 (7) , 2540-50
- https://doi.org/10.1128/jb.187.7.2540-2550.2005
Abstract
Multiple promoters drive the expression of the principal cell division gene, ftsZ , in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ - ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.Keywords
This publication has 43 references indexed in Scilit:
- Identification and Characterization of theDdlB,FtsQandFtsAGenes Upstream ofFtsZinBartonella bacilliformisandBartonella henselaeDNA and Cell Biology, 2003
- The Tubulin Ancester, FtsZ, Draughtsman, Designer and Driving Force for Bacterial CytokinesisJournal of Molecular Biology, 2002
- Differential Regulation of ftsZ Transcription during Septation of Streptomyces griseusJournal of Bacteriology, 2001
- Cloning and Characterization of ftsZ and pyrF from the Archaeon Thermoplasma acidophilumBiochemical and Biophysical Research Communications, 2000
- Control of division gene expression inEscherichia coliFEMS Microbiology Letters, 2000
- Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two‐component system rcsC–rcsBMolecular Microbiology, 1999
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- STAB‐SD: a Shine–Dalgarno sequence in the 5′ untranslated region is a determinant of mRNA stabilityMolecular Microbiology, 1996
- Expression of the division-controlling gene ftsZ during growth and sporulation of the filamentous bacterium Streptomyces griseusGene, 1994
- Developmental regulation of transcription of the Bacillus subtilis ftsAZ operonJournal of Molecular Biology, 1992