Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK–modified donor T cells after allogeneic hematopoietic cell transplantation
Top Cited Papers
Open Access
- 15 March 2006
- journal article
- Published by American Society of Hematology in Blood
- Vol. 107 (6) , 2294-2302
- https://doi.org/10.1182/blood-2005-08-3503
Abstract
The introduction of an inducible suicide gene such as the herpes simplex virus thymidine kinase (HSV-TK) might allow exploitation of the antitumor actKeywords
This publication has 62 references indexed in Scilit:
- Analyzing t-cell responses to cytomegalovirus by cytokine flow cytometryHuman Immunology, 2004
- Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate modelBlood, 2004
- Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor LymphocytesScience, 2002
- Ablation of microvessels in vivo upon dimerization of iCaspase-9Gene Therapy, 2002
- Nonmyeloablative Immunosuppressive Regimen Prolongs In Vivo Persistence of Gene-Modified Autologous T Cells in a Nonhuman Primate ModelJournal of Virology, 2001
- CD34 Splice Variant: An Attractive Marker for Selection of Gene-Modified CellsMolecular Therapy, 2000
- Retrovirus-Mediated Gene Transfer in Primary T Lymphocytes: Influence of the Transduction/Selection Process and ofex VivoExpansion on the T Cell Receptor β Chain Hypervariable Region RepertoireHuman Gene Therapy, 2000
- Genetic Modification of Human T Cells with CD20: A Strategy to Purify and Lyse Transduced Cells with Anti-CD20 AntibodiesHuman Gene Therapy, 2000
- Improved Artificial Death Switches Based on Caspases and FADDHuman Gene Therapy, 1999
- Production and culture of HSVtk transduced suicidal lymphocytes induces variable changes in the lymphocyte subset compositionBone Marrow Transplantation, 1999