Evidence that matrix recognition contributes to stabilization but not induction of LTP

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Abstract
SLICES of hippocampus were incubated with Arg–Gly–Asp (RGD) peptides known to block members of the Sntegrin class of matrix receptors. Though the peptides caused no detectable difference in the amount of long–term potentiation (LTP) expressed in the CA1 field 1–2 min after induction with high frequency stimulation, they did produce a reversible, dose dependent decay of LTP over a period of 40 min. This effect was not obtained with various non-RGD control peptides. These results suggest that stabilization of LTP requires adhesive interactions via specific matrix recognition sites, whereas induction and expression do not.

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