X-ray-induced in vitro Neoplastic transformation of human diploid cells
- 1 February 1980
- journal article
- Published by Springer Nature in Nature
- Vol. 283 (5749) , 776-778
- https://doi.org/10.1038/283776a0
Abstract
Techniques have recently been developed to identify and score quantitatively neoplastic transformation caused by X rays in cultured cells derived from rodents. Because of their relevance to estimates of human cancer risk, it is clearly desirable to carry out similar experiments with cultured cells of human origin. The present report describes for the first time the neoplastic transformation in vitro of human diploid cells by X-ray irradiation into cells which can progress in vitro into advanced stages of neoplastic development, namely, to form colonies in agar and give rise to tumours when injected into nude mice.Keywords
This publication has 10 references indexed in Scilit:
- Conditions for inhibiting and enhancing effects of the protease inhibitor antipain on x-ray-induced neoplastic transformation in hamster and mouse cells.Proceedings of the National Academy of Sciences, 1979
- Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatmentNature, 1978
- Neoplastic transformation of human diploid fibroblast cells by chemical carcinogensProceedings of the National Academy of Sciences, 1978
- Neoplastic transformation of hamster embryo cells irradiated in utero and assayed in vitroNature, 1977
- [55] Structures and activities of protease inhibitors of microbial originPublished by Elsevier ,1976
- Transformation of Mammalian Cells in vitro by Low Doses of X-raysNature, 1973
- Neoplastic Transformation In Vitro of a Clone of Adult Liver Epithelial Cells into Differentiated Hepatoma-Like Cells Under Conditions of Nutritional StressProceedings of the National Academy of Sciences, 1972
- Quantitative studies on the malignant transformation of mouse prostate cells by carcinogenic hydrocarbonsin vitroInternational Journal of Cancer, 1969
- The number of cell generations required to fix the transformed state in X-ray-induced transformation.Proceedings of the National Academy of Sciences, 1968
- Cell susceptibility to transformation by x-irradiation and fixation of the transformed state.Proceedings of the National Academy of Sciences, 1967