Cytokine production in brain of mice experimentally infected with dengue virus
- 1 January 2004
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 15 (1) , 37-42
- https://doi.org/10.1097/00001756-200401190-00009
Abstract
Dengue virus encephalopathy was experimentally induced in newborn mice by i.p. inoculation of dengue 2 virus. At 6 and 9 days post-infection, motor incoordination and posterior limb paralysis were observed with focal necrosis, apoptotic cells, perivascular inflammatory cuffing and astrocytosis, mainly in the cortex and hippocampus. Expression of dengue virus genome and mRNA encoding for TNF-alpha, IL-1alpha, IL-2, IL-6, IL-1beta, IL-12 p40, IFNalpha, and IFNbeta; in addition host survival and inflammatory response genes MAC-1, EB22, GFAP, ICAM-1 and A20, were increased, suggesting that experimental dengue encephalitis could be associated with virus replication, inflammatory cytokine production or both. Similar findings have been observed in human dengue virus infection. Therefore, our results can be useful to elucidate and support the physiopathology of the disease.Keywords
This publication has 23 references indexed in Scilit:
- Characterisation of Lymphocyte Response and Cytokine Patterns in Patients with Dengue FeverImmunobiology, 2001
- Development of a Novel Mouse Model for Dengue Virus InfectionVirology, 1999
- A 65-kDa trypsin-sensible membrane cell protein as a possible receptor for dengue virus in cultured neuroblastoma cellsJournal of NeuroVirology, 1997
- Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular and temporal expressionJournal of Neuroimmunology, 1996
- Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.Proceedings of the National Academy of Sciences, 1996
- Reactive Gliosis as a Consequence of Interleukin-6 Expression in the Brain: Studies in Transgenic MiceDevelopmental Neuroscience, 1994
- Production Of Interleukin-L (Il-L) And Il-L Inhibitor By Human Monocytes Exposed To Dengue VirusThe Journal of Infectious Diseases, 1994
- Sequence analysis of cloned dengue virus type 2 genome (New Guinea-C strain)Gene, 1989
- Human T cell responses to dengue virus antigens. Proliferative responses and interferon gamma production.Journal of Clinical Investigation, 1989
- Infection of young adult mice with dengue virus type 2Transactions of the Royal Society of Tropical Medicine and Hygiene, 1981