SV40-Related T-Antigen Expression in Human Meningiomas with Normal and G-22-Monosomic Karyotype

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Abstract
Six of 16 [human] meningiomas tested in early subcultures by indirect immunofluorescence showed SV-40 T[tumor]-antigen. Two different antisera specific for T-antigen were used. One serum gave a positive reaction with 6 tumors and the other with only two. In 1 T-antigen positive meningioma, the typical nuclear fluorescence changed, beginning with the second subculture, into an unusual brilliant granular pattern irregularly distributed over the nuclei. In 6 meningiomas, a specific chromosome aberration (monosomy G 22) was established. Up to now, no clear correlation between karyotype and T-antigen expression could be found: cells from 3 meningiomas with positive reactions had normal karyotypes, whereas those from 3 tumors with typical chromosome loss showed no T-antigen.