Histamine potentiates neuronal excitation by blocking a calcium-dependent potassium conductance
- 1 May 1984
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 14 (3-4) , 534-537
- https://doi.org/10.1007/bf01973865
Abstract
Histaminergic neurones send their axons to the whole forebrain. The diffuse projection is consistent with a modulatory role of these pathways. In hippocampal slices from rats a mechanism for this modulation is described, on pyramidal neurones of the CA 1 area: Strong excitations induced by intracellular current injection, ionophoretic administration of glutamate or synaptic stimulation normally restrict themselves by the activation of the calcium-dependent potassium current (gK(Ca)). This current causes a long lasting afterhyperpolarization and an accommodation of firing. Their block by histamine and impromidine (reversed by metiamide and cimetidine) leads to a profound potentiation of excitatory signals. It is suggested that HA, through H2 receptors, accelerates the removal of intracellular free Ca++ ions.Keywords
This publication has 13 references indexed in Scilit:
- Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cellsNature, 1983
- Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmissionNature, 1982
- Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampusNature, 1982
- Histamine modulates reactivity of hippocampal CA3 neurons to afferent stimulation in vitroBrain Research, 1981
- Histamine hyperpolarizes hippocampal neurones in vitroNeuroscience Letters, 1981
- A simple perfusion chamber for the study of nervous tissue slices in vitroJournal of Neuroscience Methods, 1979
- Sustained extracellular potentials in the cat spinal cord during the microiontophoretic application of excitatory amino acidsJournal of Neuroscience Methods, 1979
- Specific long-lasting potentiation of synaptic transmission in hippocampal slicesNature, 1977
- Central actions of histamine: Microelectrophoretic studiesBrain Research, 1977
- Histaminergic Pathway in Rat Brain Evidenced by Lesions of the Medial Forebrain BundleScience, 1974