SILENT ALLELES AT HLA-C-LOCUS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 121  (2) , 731-735
Abstract
Defined specificities of the HLA-C locus possess a significantly lower immunogenicity as compared with the HLA-A and HLA-B specificities. HLA-C blanks are not immunogenic at all. Among the possible explanations, the most likely one appears to be a low phenotypic expression of these alleles. C locus antigens as a whole are thus likely to be of minor relevance in donor/recipient matching for transplantation.

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