EXTRA-HEPATIC BILIARY ATRESIA - MORPHOLOGICAL-STUDY OF 98 BILIARY REMNANTS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (8) , 397-402
Abstract
Histologic examination was performed on 98 biliary remnants [from children]. Classification into 3 types was made according to the presence of epithelial structure; biliary and glandular formations were separated. Atretic lesions were predominantly observed at the pars inferior of the remnants. These histological findings agree with the theory of a dynamic ascending process that leads to progressive, complete destruction of the biliary and glandular structure, although main ducts may remain preserved by the vicinity of the porta hepatis. The damage is probably initiated in utero. The lesions certainly progress after birth; In some cases the fibrotic process of the remnant may have already reached completion at birth, whereas in some others it may become clinically evident after birth.

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