A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt(IV)enX2A2 , with X2 = cyclobutane‐1,1‐dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3α, 12α ‐diformoxy‐5β‐cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR (1H and 13C) spectroscopic techniques. Previous platinum(IV) compounds were usually restricted to trans‐dihydroxo or trans‐dichloro platinum(IV) complexes. Recently trans‐dicarboxylato platinum(IV) complexes with mainly acetate, trifluoracetate or short‐chain carboxylate groups ([1,2,3]. In this paper we report on the synthesis and characterization of a new class of ethylenediamine platinum(IV) compounds that have high lipophilic long‐chain carboxylate ligands either in the axial or equatorial position. The platinum(IV) compounds with the lipophilic trans‐carboxylate ligands in the axial position were prepared by acylation of the trans‐dihydroxo platinum(IV) species using an acyl halide in the presence of pyridine. In contrast to previous publications[1] the yields were excellent (up to 94%!).