Neurogranin, a B‐50/GAP‐43‐immunoreactive C‐kinase substrate (BICKS), is ADP‐ribosylated

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Abstract
Neurogranin is a neurone‐specific, B‐50‐immunoreactive C‐kinase substrate that has limited homology to, but considerable biochemical similarity to B‐50/GAP43. The most significant differences between these two proteins are their cellular localisation and molecular mass (Neurogranin, 7.5 kDA cytosolic; and B‐50, 25 kDa membranal). An understanding of the similarities and differences between Neurogranin and B‐50 may facilitate the elucidation of their hitherto elusive functions in the nervous system. The results of the present study demonstrate that, in common with B‐50, Neurogranin is a substrate for ADP‐ribosyltransferases. This finding is discussed with regard to the concept of molecular flexibility of B‐50‐like proteins as the basis of their putatively diverse roles in the nervous system.