Galactorrhea-Amenorrhea, Brom-Ergocryptine, and the Dopamine Receptor

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Abstract
Inappropriate secretion of prolactin is now recognized as one of the important causes of galactorrhea of diverse origin, including that seen after disruption of the portal circulation connecting the hypothalamus and the pituitary, after administration of certain drugs, including birth-control pills, after pregnancy, in some patients with chromophobe pituitary tumors and in women with no clinically detectable disease of pituitary or hypothalamus. Patients with hyperprolactinemia usually have amenorrhea as well. This complication occurs most often because the high prolactin levels interfere either with the secretion of hypothalamic luteinizing hormone-releasing hormone (LH-RH) or with the direct effects of the gonadotrophins on . . .