Half-Lives of Sulphadoxine and Trimethoprim After a Single Intravenous Infusion in Cows

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Abstract
DAVITIYANANDA, DANIS and FOLKE RASMUSSEN: Half-lives of sulphadoxine and trimethoprim after a single intravenous infusion in cows. Acta vet. scand. 1974, 15, 356–365. — The half-life of sulphadoxine in plasma (11 hrs.) is much longer than that of trimethoprim (50–103 min.) and in accordance to this traces of sulphadoxine are demonstrated in the milk 3 days after the infusion, while trimethoprim could not be detected in milk 2 days after the infusion. The apparent volume of distribution is 0.37 for sulphadoxine and 1.14 for trimethoprim, i.e. 37 % and 114 % of the body weight, respectively. sulphadoxine; trimethoprim; half-life; cow.