Dose response of topical carbamylcholine chloride (carbachol) in normotensive and early glaucomatous Beagles

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Abstract
SUMMARY: Single-dose loading with a placebo (0.5% methylcellulose) and 0.75%, 1.5%, 2.25%, or 3% carbamylcholine chloride (carbachol) was evaluated in normotensive and glaucomatous Beagles to determine dose response. The 4 carbachol concentrations significantly (P < 0.05) lowered intraocular pressure and reduced pupil size in the normotensive and early glaucomatous Beagles at most time intervals as compared with baseline values, nontreated fellow eyes, and placebo-treated eyes. There were no significant (P < 0.24) effects on intraocular pressure or pupil size by unilateral carbachol instillations as compared with base-line values or placebo-treated eyes.

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