Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate

Open Access
Publisher Website
Google Scholar
Abstract
Summary: Cellulose sulphate, a kinin‐releasing agent, produced fibrinolytic activity in plasma when administered intravenously to the rat but not when added to fresh rat plasma in vitro. The in vivo effect was maximal within 1 min and disappeared within 10–20 minutes. It was retained in plasma taken 1 min after the injection and kept at room temperature for 30 minutes. A decrease of anti‐fibrinolytic potency measured against urokinase‐activated bovine plasmin, was shown to occur in plasma of rats given cellulose sulphate. Activated rat plasma lysed heat‐denatured fibrin: it probably contains free plasmin as well as plasminogen activator. Adrenalectomized rats did not exhibit fibrinolytic activity nor statistically significant benzoyl‐arginine ethyl ester‐esterase activation in plasma after cellulose sulphate treatment. Adrenalectomized rats had significantly increased levels of plasma kininogen, but were normally sensitive to the kininogen‐depleting action of cellulose sulphate. The increased plasma kininogen of adrenalectomized rats seems to be a consequence of the impairment of the plasminogen activating mechanism.