Are Cell Number and Cell Proliferation Risk Factors for Cancer?1
- 20 July 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 80 (10) , 772-775
- https://doi.org/10.1093/jnci/80.10.772
Abstract
Relatively little is known about the mechanisms underlying carcinogenesis in humans. Caloric restriction strongly inhibits the development of neoplasia in rodents, and there is evidence of a positive relationship between cancer and body weight in humans. Caloric restriction early in life is also known to permanently diminish organ cellularity. A recent link between adult stature and cancer incidence similarly implicates a lasting effect for growth and possibly for early nutrition in carcinogenesis. It is, postulated that cancer risk is pro-portional to the number of proliferating cells, which in turn depends on both the number of cells and the rate of cell division within the tissue. This hypothesis is consistent with several aspects of human carcinogenesis, including multistage models and the epithelial origin of most cancers. [J Natl Cancer Inst 1988;80:772–775]This publication has 1 reference indexed in Scilit:
- Body Mass Index as a Predictor of Cancer in Men2JNCI Journal of the National Cancer Institute, 1985