The L-type calcium channel in the heart: the beat goes on

Open Access

1 December 2005

journal article
review article
Published by American Society for Clinical Investigation in Journal of Clinical Investigation

Vol. 115 (12) , 3306-3317
https://doi.org/10.1172/jci27167

Abstract

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca²⁺. Fascination with the role of Ca²⁺ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca²⁺ and the L-type voltage-dependent Ca²⁺ channels in cardiac disease.

Keywords

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