Androgen Metabolism in the Skin of Hirsute Women1
- 1 January 1974
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 38 (1) , 19-22
- https://doi.org/10.1210/jcem-38-1-19
Abstract
The metabolism of 73H-dehydroisoandrosterone and of 1,23H-testosterone has been studied in skin removed from the linea alba of hirsute and normal women, and also in one normal and one hypogonadal man. After 4 hr incubation, utilization of dehydroisoandrosterone was between 13 and 25% in 5 normal women (mean 19 ± 2.1 se percent), 32% in the hypogonadal man, between 40 and 65% in hirsute women (mean 52 % 4.0 se percent), and 72% in the normal man. Of the metabolites formed, the relatively weak 17 ketosteroids predominated but a greater proportion of active androgens, testosterone, dihydrotestosterone and androstanediol,2 was found in the skin of hirsute women and in normal male skin. There was no difference in the utilization of testosterone except in the normal man where conversion was high.Keywords
This publication has 0 references indexed in Scilit: