Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG
- 1 February 2007
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 17 (3) , 814-818
- https://doi.org/10.1016/j.bmcl.2006.10.053
Abstract
No abstract availableKeywords
This publication has 20 references indexed in Scilit:
- Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivoObesity Reviews, 2006
- 6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: Structure–activity exploration of eastern and western partsBioorganic & Medicinal Chemistry Letters, 2006
- Recent developments in the discovery of MCH-1R antagonists for the treatment of obesity – an updateExpert Opinion on Therapeutic Patents, 2005
- Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1Bioorganic & Medicinal Chemistry Letters, 2005
- Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of ObesityJournal of Medicinal Chemistry, 2005
- Identification of 2-(4-Benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an Orally Efficacious Melanin-Concentrating Hormone Receptor 1 Antagonist for the Treatment of ObesityJournal of Medicinal Chemistry, 2005
- 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonistsBioorganic & Medicinal Chemistry Letters, 2004
- Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesityExpert Opinion on Investigational Drugs, 2004
- Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in ratsPublished by Elsevier ,2003
- Melanin-concentrating hormone receptor antagonists as potential antiobesity agentsExpert Opinion on Therapeutic Patents, 2002