Effective Phototherapy in Congenital Nonobstructive, Nonhemolytic Jaundice

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Abstract
CONGENITAL nonobstructive, nonhemolytic jaundice (the Crigler—Najjar syndrome) is characterized by the presence of indirect hyperbilirubinemia caused by a deficiency in the activity of the transferase forming bilirubin glucuronide.1 In 80 per cent of those affected "kernicterus" develops, usually early in childhood or in some cases after a long asymptomatic course.2 Attempts have been made to lower the concentration of serum bilirubin by the use of resins3 or by exchange transfusion or hemodialysis (or both).2 These measures have had only limited success. More recently, phenobarbital has been demonstrated to decrease serum bilirubin in some but not all cases of the Crigler—Najjar . . .