Amniotic Fluid Embolism

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Abstract
IN THE massive body of medical literature that has accumulated over the last century, there are occasional contributions that provide such an elemental description of a clinicopathologic disease entity that subsequent decades of research and meticulous study fail to substantially improve on the original. Such a work is this issue's LANDMARK ARTICLE, the description of amniotic fluid embolism by Steiner and Lushbaugh.1 Although the fields of pathology and obstetrics have both changed markedly in the 45 years since the publication of this article, the fundamental information therein continues to be germane. In many respects, the little gains in knowledge of the pathogenesis, diagnosis, and course of amniotic fluid embolism since 1941 have been the result of advances in technology, most notably central monitoring catheters, to aid in both antemortem diagnosis and characterization of the clinical and physiological manifestations of this fulminating, often fatal event. A Subset of Deaths The

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