8-Methyl-Pyridoxatin: A Novel N-Hydroxy Pyridone from Fungus OS-F61800 That Induces Erythropoietin in Human Cells
- 28 January 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (2) , 397-399
- https://doi.org/10.1021/np980450t
Abstract
In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive 1H and 13C NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 μM, which is about threefold greater potency than our previously identified erythropoietin inducers.Keywords
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