Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies
- 1 November 2000
- journal article
- review article
- Published by S. Karger AG in Neonatology
- Vol. 78 (4) , 269-276
- https://doi.org/10.1159/000014278
Abstract
Many plastic items are made of polyvinylchloride (PVC) blended with plasticizers. The most frequently used plasticizer is di-(2-ethylhexyl)-phthalate (DEHP). DEHP migrates at a constant rate from plastics to the environment: it has been detected in water, soil and food and is therefore considered as a widespread environmental contaminant. Over the past several years, a number of publications concerning toxic effects of DEHP on animals and humans have been reported. Although DEHP is suggested to be of low acute toxicity, long-term exposure, especially in human beings at risk such as pregnant women and children, requires more in-depth studies. If DEHP toxicity in humans were to be confirmed, it would be advisable in the future to replace current PVC plasticizers, especially if they come into contact with babies, with better-quality materials.Keywords
This publication has 18 references indexed in Scilit:
- In vitro and in vivo studies of the effect of the concentration of plasticizer di(2-ethylhexyl) phthalate on the blood compatibility of plasticized poly(vinyl chloride) drain tubesBiomaterials, 1995
- Di-(2-ethylhexyl) Phthalate Suppresses Estradiol and Ovulation in Cycling RatsToxicology and Applied Pharmacology, 1994
- Exposure of newborn infants to di‐(2‐ethylhexyl)‐phthalate and 2‐ ethylhexanoic acid following exchange transfusion with polyvinylchloride cathetersTransfusion, 1993
- Metabolism of oxygen radicals in peroxisomes and cellular implicationsFree Radical Biology & Medicine, 1992
- Glucuronidation of mono(2-ethylhexyl)phthalate: Some enzyme characteristics and inhibition by bilirubinBiochemical Pharmacology, 1991
- What price progress? An update on vinyl plastic bagsTransfusion, 1989
- Alterations in the thyroids of rats treated for long periods with di-(2-ethylhexyl) phthalate or with hypolipidaemic agentsToxicology Letters, 1988
- Exposure of newborn infants to plasticizers: Plasma levels of di‐(2‐ ethylhexyl) phthalate and mono‐(2‐ethylhexyl) phthalate during exchange transfusionTransfusion, 1985
- Di-(2-ethylhexyl) phthalate enhances the release of lysosomal enzymes from alveolar macrophages during phagocytosisToxicology, 1980
- Migration of plasticizer from hemodialysis blood tubing. Preliminary reportJAMA, 1975