EFFECT OF A VASOPRESSIN ANALOG (NALPHA-GLYCYL-GLYCYL-GLYCYL-[8-LYSINE]-VASOPRESSIN) ON ORGAN BLOOD-FLOW IN PREGNANT GUINEA-PIG

  • 1 January 1977
    • journal article
    • research article
    • Vol. 40  (3) , 369-377
Abstract
N.alpha.-triglycyl-(8-lysine)-vasopressin (TGLVP) was administered i.v. to pregnant guinea pigs and the effect on regional blood flow examined by the radioactive microsphere technique. A dose of 10 .mu.g/kg TGLVP caused an elevation of the mean arterial blood pressure, from 6.4 to 11.1 kPa [kilo Pascal], a significant reduction in blood flow to the gut, skin and skeletal muscle, and a significant increase in blood flow to the spleen. The number of 15 .+-. 5 .mu.m microspheres reaching the lungs diminished significantly after 10 .mu.g/kg TGLVP, indicating that this dose constricted arteriovenous short circuits in the systemic circulation. There was also a decrease in blood flow to the urogenital tract, including the placentae. When 3 .mu.g/kg TGLVP was injected, the mean arterial blood pressure rose from 6.5 to 8.7 kPa and there was no longer any consistent effect on maternal placental blood flow. Pregnancy apparently constitutes a contraindication for TGLVP, since a reduction in uterine and maternal placental blood flow might occur with clinically relevant doses.

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