SKIN-LESIONS IN LONG-TERM DIALYSIS PATIENTS - A CLINICAL-STUDY

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 33  (6) , 303-309
Abstract
Hemodialysis patients (51) underwent clinicodermatologic examination. Of them 23 were on regualr hemodialysis for 2-3 yr (group 1), 28 patients for > 8 yr (group 2). Both groups were matched in regard to primary kidney disease, age and sex. A characteristic feature found was a marked premature aging of the skin, mainly imposing as actinic elastosis. The incidence was related to the duration of hemodialysis (56.5% of patients of the 1st group and 100% of patients of the 2nd group). There was also a correlation between time on hemodialysis and an increase of skin pigmentation. Other phenomena like xeroderma, decrease of sebaceous and sweat gland secretion, and Raynaud syndrome were also seen more frequently in the 2nd group, but the extent of these alterations was equal in both groups. Of the patients, 78% of the 1st group and 43% of the 2nd group suffered from generalized pruritus. Two different forms of pruritus could be observed, one possibly atopic, only occurring during regular hemodialysis, the other occurring independent of hemodialysis. Accumulation of rare phenomena like carpal-tunnel syndrome and Dupuytren''s contractures in group 2 together with the frequent occurrence of actinic elastosis implies systemic disturbance of collagen metabolism in long-term regular hemodialysis patients.

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