Virulence of Mycobacterium tuberculosis and Susceptibility to Peroxidative Killing Systems

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Abstract
At sub-bactericidal concentrations of H2O2, M. tuberculosis was killed by H2O2/peroxidase/halide microbicidal systems. The halide cofactor could be either iodide or, with much lower efficiency, chloride. Omission of any 1 of the reactants eliminated the tuberculocidal effect. Differences in susceptibility between different strains of M. tuberculosis did not correlate with virulence differences. The observations are discussed in the context of host defense mechanisms against tuberculosis.

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