Complementation analysis in lymphoid cells from five patients with different forms of maple syrup urine disease
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 68 (1) , 54-56
- https://doi.org/10.1007/bf00293872
Abstract
The possibility of genetic heterogeneity in maple syrup urine discase was investigated by measuring branchedchain ketoacid dehydrogenase in polyethylene glycol-induced heterokaryons of lymphoid cells. The lymphoid cell lines from five patients with varying forms of the disease were establisjed after incubation with Epstein-Barr virus. The results suggested that there are at least two genetic complementation groups in the disease.Keywords
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