Suppression of neuronal potassium A‐current by arachidonic acid
- 6 December 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 335 (2) , 184-188
- https://doi.org/10.1016/0014-5793(93)80726-b
Abstract
The effect of arachidonic acid on the A current (I A) has been studied in dissociated bullfrog neurons under whole‐cell voltage‐damp conditions. Arachidonic acid reduced I A in a dose‐dependent and reversible manner without a shift in the prepulse inactivation voltage‐current relation. 1.75 μM inhibited i A by 50%, and higher concentrations caused a total suppression. In addition, arachidonic add increased the M‐current (I M), a different potassium current that does not inactivate. Neither indomethacin nor nordihydroguaiaretic acid, cyclooxygenase and lipoxygenase inhibitors respectively, prevented I A reduction. In contrast, nordihydroguaiaretic acid prevented I M enhancement. Eicosatetraynoic acid, an arachidonic acid analog that cannot be metabolized, also reduced I A. These results suggest that arachidonic acid metabolism is not required to suppress I AKeywords
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