Immunohistochemical localization of dipeptidyl peptidase IV in rat digestive organs.

Publisher Website
Google Scholar
Abstract
Immunohistochemical localization of dipeptidyl peptidase (DPP) IV in rat digestive organs was studied using the peroxidase-antiperoxidase (PAP) method. A fairly intense immunoreaction of DPP IV was found on the brush border of enterocytes of the small intestine. However, the immunostaining of enterocytes in the small intestine showed marked regional differences. The intensity of the reaction was significantly higher in the jejunum and ileum than in the duodenum. DPP IV was also detected in the cytoplasm of Paneth cells in the jejunum and ileum and on the surface of the crypt epithelium of the colon. In the esophagus, a faint reaction was detected on the surface of the stratified epithelium and connective tissues of the submucosa. DPP IV could not be found in the cells of the stomach by immunohistochemical means. DPP IV in digestive organs probably participates in the final stage of peptide digestion in which a proline residue is involved.

This publication has 0 references indexed in Scilit: