THE MECHANISM OF THE EXCRETION OF VITAMIN C BY THE DOG KIDNEY

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Abstract
Simultaneous vit. C and creatinine clearances were done on 4 normal dogs. The results showed that ascorbic acid was excreted by filtration and active tubular reabsorption. The reabsorptive mechanism for vit. C was limited by a maximal rate so that when the vit. was presented to the tubules by the glomerular filtrate at a rate exceeding this maximum the excess was excreted in the urine. The avg. for this maximal rate was 0.52 mg per 100 cc of filtrate. Vit. C was not reabsorbed by the same mechanism as glucose.

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