Nrf2 Controls Constitutive and Inducible Expression of ARE-driven Genes through a Dynamic Pathway Involving Nucleocytoplasmic Shuttling by Keap1
Open Access
- 1 September 2005
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 280 (37) , 32485-32492
- https://doi.org/10.1074/jbc.m503074200
Abstract
No abstract availableKeywords
This publication has 49 references indexed in Scilit:
- BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 LigaseMolecular and Cellular Biology, 2005
- Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase ComplexMolecular and Cellular Biology, 2004
- Redox-regulated Turnover of Nrf2 Is Determined by at Least Two Separate Protein Domains, the Redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 DegronJournal of Biological Chemistry, 2004
- Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene ExpressionJournal of Biological Chemistry, 2003
- Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell SurvivalMolecular and Cellular Biology, 2003
- Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activationNature Genetics, 2003
- Regulatory Mechanisms Controlling Gene Expression Mediated by the Antioxidant Response ElementAnnual Review of Pharmacology and Toxicology, 2003
- Degradation of Transcription Factor Nrf2 via the Ubiquitin-Proteasome Pathway and Stabilization by CadmiumJournal of Biological Chemistry, 2003
- Microarray Analysis Reveals an Antioxidant Responsive Element-driven Gene Set Involved in Conferring Protection from an Oxidative Stress-induced Apoptosis in IMR-32 CellsJournal of Biological Chemistry, 2002
- High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant GenesToxicological Sciences, 2001