Strophanthidin-induced sodium efflux

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Abstract
The external cation dependence of a strophanthidin-induced Na efflux in dialysed axons was examined. In the presence of strophanthidin the replacement of external Na with choline produced no appreciable changes in Na efflux, whereas the replacement of external Na with Mg brought about a large and reversible reduction. In the absence of external Ca the absolute magnitude of the reduction in Na efflux seen in Mg seawater was the same regardless of the ATP content of the axons; this reduction was similar to that observed in the presence of external calcium in low ATP axons. The present results, together with others already reported in the literature, suggest that the strophanthidin-induced Na efflux represents the outward component of an exchange of ions in which internal Na is exchanged for external monovalent cations.

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