Rearrangements at the mating type locus in fission yeast

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Abstract
Crosses involving the partially defective mating type mutant B102 (functional in conjugation, defective in meiosis) have confirmed the notion that, in Schizosaccharomyces pombe, certain mating type mutations can arise by transposition. A copy of the mat2 P segment (specifying + mating type) is transposed and inserted into the mat1 M segment (usually specifying ⊖ mating type). The mat1 M segment affected by the insertion loses its former ⊖ function entirely. The ⊖ function is, however, fully regained upon excision of the transposed and inserted mat2 P segment. At either position, the mat2 P segments can undergo inactivations to different states of residual activity. These events can occur about as frequent as other mutations of the mating type locus (ca. 10−4 per cell division). In certain diploid strains, such inactivations were significantly correlated with recombination. Spontaneous reversions to full activity were also observed.

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