Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action
- 1 November 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (11) , 2250-2256
- https://doi.org/10.1021/jm00161a020
Abstract
Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-.alpha.-methylphenethylamine (5) and 4-amino-2-chloro-.alpha.-methylphenethylamine (4).This publication has 12 references indexed in Scilit:
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