DETERMINATION OF THE OPTIMAL CONCENTRATION OF LITHIUM FOR THE PROPHYLAXIS OF MANIC-DEPRESSIVE DISORDER

  • 1 January 1982
    • journal article
    • research article
    • Vol. 17  (11) , 1323-1329
Abstract
A group of 29 bipolar manic depressives completed a 12-mo. double-blind crossover trial of low-dose and high-dose Li prophylaxis. Twelve patients relapsed, and significantly more of the relapses occured during the low-dose 6-mo. phase of the trial. There was a trend for relapse to occur within 2 mo. of an abrupt drop in plasma Li level and to occur more often in women than in men. The efficacy of low-dose Li prophylaxis and the significance of rebound relapse are discussed.

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