L-DOPA Poisioning

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Abstract
The medical therapy for Parkinson's disease, especially in younger patients, has recently included L-DOPA, the generic name for levodihydroxyphenylalanine. The prescribed therapeutic amounts of this drug have been suggested and the resulting circulating blood concentrations documented [1]. We have recently observed what appears to be the first death from an overdose of this drug, affording an opportunity to perform distribution studies on the tissues and fluids. Meprobamate and flurazepam (Dalmane) were also recovered, but in trace to therapeutic amounts.

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