Isotype responses of mice to tetanus-toxoid preparations
- 1 November 1986
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 22 (3) , 189-193
- https://doi.org/10.1099/00222615-22-3-189
Abstract
The development of anti-tetanus antibodies in CBA/Ca and Balb/c mice immunized with two tetanus-toxoid preparations has been investigated by sensitive enzyme-linked immunoassays. These studies revealed the presence in both strains of mice of naturally occurring antibodies to tetanus toxoid. These were of the IgM, IgA and, to a lesser extent, the IgG3 isotypes. Differences in the responses of mice to the two toxoid preparations were noted; the purer preparation elicited a more rapid and pronounced response. Both strains of mice exhibited similar isotype responses.This publication has 1 reference indexed in Scilit:
- Subclass Restriction of Murine Anti-Carbohydrate AntibodiesThe Journal of Immunology, 1978