Effect of acute administration of cadmium on distribution of zinc in the hamster

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Abstract
Acute administration of s.c. doses of Cd (1 mg/kg .cntdot. day, 3 or 6 days) to male golden hamsters resulted in a remarkable dose-dependent increase of Zn in the liver and kidney. Zn contents in the heart and testes showed a significant dose-dependent decrease. No change was found in Zn contents of the bone. The correlation coefficients between contents of Cd and Zn in the liver and kidney were higher in metallothionein fractions than in the corresponding whole organs. Cd induced the synthesis of metallothionein in the liver and kidney, leading to simultaneous accumulation of Cd and Zn in the organs; this decreased the Zn contents in other organs, where weak or no induction of metallothionein synthesis took place. Cd might induce Zn deficiency in humans or animals whose pool size and intake of Zn are marginal.