3-Hydrazinopyridazine derivatives as inhibitors of pyridoxal-phosphate dependent enzymes.

  • 1 October 1980
    • journal article
    • Vol. 35  (10) , 848-55
Abstract
A series 3-hydrazinopyridazine derivatives with anti-hypertensive properties was studied as inhibitors of pyridoxal-phosphate dependent enzymes. All the compounds with a free hydrazino group were found to be strong inhibitors in vitro. In vivo inactive compounds became active at doses which exert a hypotensive action. The significance of this inhibition is discussed.

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