Effects of Acetazoleamide, Chlorothiazide, and Dichlorphenamide on Electrolyte Excretion in the Alligator.

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Abstract
Prolonged administration of acetazoleamide to alligators leads to the excretion of considerable amounts of chloride, producing an alkalemia. Continued K excretion also occurs which has little effect on the plasma level, presumably due to a removal of K from the cells in an effort to compensate for the loss. No evidence of the development of a refractory state to acetazoleamide after 30 days of injections was noted nor was there any sign that the decreased plasma Cl prevented the excretion of Cl. The degree of K loss was not directly correlated with H ion excretion. Two new carbonic anhydrase inhibitors, chlorothiazide and dichlorphenamide were tested. Dichlorphenamide was more active in promoting K and Cl loss at low dose levels than acetazoleamide. Chlorothiazide showed no significant activity.

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