A double gene dose of mutant alleles at the W or Sl locus produces the pleiotropic effects of anemia, sterility, lack of hair pigmentation and lack of tissue mast cells. Coincidental development of forestomach papilloma and prepyloric ulcer was observed in .apprx. 40% or nontreated (WB .times. C57BL/6) F1-W/Wv mice. The stomach lesions of the W/Wv mice could be detected at the 15th day after birth, and such lesions never appeared in the W/ +, Wv/+ and +/+ littermates maintained under the same laboratory conditions. Since the stomach lesions were also observed in (WC .times. C57BL/6) F1-Sl/Sld mice purchased from The Jackson Laboratory, Maine, USA, phenotypes common to W/Wv and Sl/Sl/d mice seem to play an essential role in the spontaneous development of the forestomach papilloma and prepyloric ulcer.