First‐trimester screening for fetal chromosomal abnormalities. Preliminary results

1 August 1991

journal article
research article
Published by Wiley in Prenatal Diagnosis

Vol. 11 (8) , 621-624
https://doi.org/10.1002/pd.1970110819

Abstract

We have started a multicentre trial to study the possibilities of first-trimester maternal serum screening for fetal chromosomal abnormalities. Maternal blood samples were obtained before 13 weeks of gestation. We present the preliminary results of the first 950 patients on alpha-fetoprotein (AFP). Results on cancer antigen 125 (CA 125) in Down's syndrome and normal pregnancies are also presented. We conclude that the results on AFP are promising and that CA 125 might be predictive for fetal Down's syndrome.

Keywords

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