SYNTHESIS OF A TETRACONTAPEPTIDE, HYPOTHETICAL ANCESTOR OF CALCIUM-BINDING PROTEINS .1. SYNTHESIS OF FRAGMENTS (1-9), (10-14), (15-20), (21-26), (29-33) AND (34-40)

1 November 1987

journal article
research article

Vol. 13 (11) , 1465-1473

Abstract

Fragments (1.sbd.9), (10.sbd.14), (15.sbd.20), (21.sbd.26), (29.sbd.33) and (34.sbd.40) of a tetracontapeptide hypothetical ancestor of calcium-binding protein were synthesised with the use of pentafluorophenyl esters. Formation of a succinimide derivative was detected during synthesis of fragment (15.sbd.20) containing Asp(OBz)-Gly sequence. To avoid this side process, tert-butylprotecting group was used instead of benzyl group. .alpha.-Carboxyls of C-terminal amino acids were detected by phenacyl group.

This publication has 2 references indexed in Scilit:

USE OF CYCLOPENTYL ESTER PROTECTION FOR ASPARTIC ACID TO REDUCE BASE CATALYZED SUCCINIMIDE FORMATION IN SOLID‐PHASE PEPTIDE SYNTHESIS
International Journal of Peptide and Protein Research, 1979
SIDE REACTIONS IN PEPTIDE-SYNTHESIS .6. RE-EXAMINATION OF BENZYL GROUP IN PROTECTION OF SIDE-CHAINS OF TYROSINE AND ASPARTIC-ACID
1978