Synthesis of the Bicyclo[4.4.1]decenone Core of CP-225,917 and CP-263,114
- 1 May 1998
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1998 (5) , 552-553
- https://doi.org/10.1055/s-1998-1699
Abstract
The bicyclo[4.3.1]decenone core of the ras-farnesyl protein transferase inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction.Keywords
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