Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin A
- 21 December 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4681) , 1439-1441
- https://doi.org/10.1126/science.6334364
Abstract
Cyclosporin A blocked production of the lymphokine interleukin 2 by activated T lymphocytes. In a human and a murine cell line this inhibition reflected an absence of interleukin 2 messenger RNA. Under conditions in which these cells are normally stimulated to secrete high levels of interleukin 2, they failed to do so in the presence of cyclosporin A. In both cell lines this failure was accompanied by an absence of interleukin 2 messenger accumulation.This publication has 14 references indexed in Scilit:
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