The effect of selective gastric or extragastric vagotomy on gastric secretion in conscious cats

Publisher Website
Google Scholar
Abstract
Earlier studies in dogs showed that in animals with gastric fistulas, selective gastric vagotomy decreased maximal acid secretion in response to gastrin but not to histamine, and that in animals with Heidenhain pouches, selective extragastric vagotomy increased maximal response to gastrin but not to histamine. The present study sought to determine whether similar changes occurred in cats. In cats with gastric fistulas, selective gastric vagotomy reduced maximal response to pentagastrin and to histamine by about the same extent. In cats with Heidenhain pouches, selective extragastric vagotomy had no effect on the response to pentagastrin. It is concluded that there is a species difference between the dog and the cat regarding the effects of selective gastric and selective extragastric vagotomy on gastric acid secretion in response to gastrin. It is not yet known whether man fits the pattern of the dog or the cat.
Funding Information
  • Veterans Administration research (AM8354)
  • United States Public Health Service