Mechanistic studies on pregnene side-chain cleavage enzyme (17α-hydroxylase-17,20-lyase) using18O
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 3,p. 157-159
- https://doi.org/10.1039/c39910000157
Abstract
In the conversion of pregnenolone 1 into dehydroisoandrosterone 3 and 3β-hydroxyandrosta-5,16-diene 5 an atom of oxygen from O2 is incorporated into the side chain released as acetate; during the conversions the C-21 methyl hydrogens of the precursor are not disturbed, the status of 16α and 17α hydrogen atoms during the conversions is also defined.Keywords
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